Transcriptome sequencing wide functional analysis of human hepatocellular carcinoma in response to BRD4 inhibition

We investigated that differentially expressed genes (DEG) targeted by BET inhibitors, JQ1 and OTX-015 in HCC cells using RNA sequencing. These DEGs are involved in HCC cells migration, of which SMARCA4 inhibition is effective in suppressing HCC cell migration. The gene expression profile was performed with control HepG2 (Con), JQ1-treated HepG2 (JQ1), OTX-015-treated HepG2 (OTX). Samples were generated by deep sequencing, in triplicate, using Illumina HiSeq 2500.