A multi-centre randomized trial comparing Radiofrequency Ablation with Radical Endoscopic Resection for treatment of Barrett’s Esophagus with High-grade Dysplasia or Early Cancer.

Interventions: Stepwise radical endoscopic resection (RER), or radiofrequency ablation (RFA) Primary outcome(s): 1. Rate of total histological eradication of HGD and/or EC 2. Rate of total endoscopic eradication of Barrett’s mucosa 3. Rate of total histological eradication of Barrett’s mucosa Study Design: Randomized controlled trial, Open (masking not used), N/A , unknown, Parallel