Ancient synteny links metabolism with erythroid development

In order to examine the link between Nprl3 regulation of cellular metabolism and erythropoiesis, we performed RNA-seq and identified gene expression changes in Nprl3 +/- and Nprl3 -/- mouse fetal liver erythroblasts compared with wild type Nprl3 +/+ erythroblasts. Poly(A)+ mRNA was analysed from four Nprl3 +/+ fetal livers (2 male, 2 female), two Nprl3 +/- fetal livers (2 male) and two Nprl3 -/- fetal livers (1 male, 1 female).