Diastereo- and Enantioselective [3 + 2] Cycloaddition Reaction of Morita–Baylis–Hillman Carbonates of Isatins with <i>N</i>-Phenylmaleimide Catalyzed by Me-DuPhos
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资源简介：
A Me-DuPhos-catalyzed efficient asymmetric [3 + 2] cycloaddition reaction between Morita–Baylis–Hillman carbonates of isatins and N-phenylmaleimide has been developed. This reaction constructs three chiral centers in one step to afford spirocyclopentaneoxindoles in good yields (up to 84%) with excellent diastereo- and enantioselectivies (up to 99% ee).
创建时间：
2012-04-20
