DataSheet_1_Brown fat triglyceride content is associated with cardiovascular risk markers in adults from a tropical region.docx

Brown adipose tissue (BAT) is regarded as an interesting potential target for the treatment of obesity, diabetes, and cardiovascular diseases, and the detailed characterization of its structural and functional phenotype could enable an advance in these fields. Most studies evaluating BAT structure and function were performed in temperate climate regions, and we are yet to know how these findings apply to the 40% of the world’s population living in tropical areas. Here, we used 18F-fluorodeoxyglucose positron emission tomography – magnetic resonance imaging to evaluate BAT in 45 lean, overweight, and obese volunteers living in a tropical area in Southeast Brazil. We aimed at investigating the associations between BAT activity, volume, metabolic activity, and BAT content of triglycerides with adiposity and cardiovascular risk markers in a sample of adults living in a tropical area and we showed that BAT glucose uptake is not correlated with leanness; instead, BAT triglyceride content is correlated with visceral adiposity and markers of cardiovascular risk. This study expands knowledge regarding the structure and function of BAT in people living in tropical areas. In addition, we provide evidence that BAT triglyceride content could be an interesting marker of cardiovascular risk.

棕色脂肪组织（BAT）被视为治疗肥胖、糖尿病和心血管疾病的有潜力的靶点，对其结构及功能表型的详细描述有望推动相关领域的发展。多数评估BAT结构和功能的研究均在温带气候区域进行，而关于这些发现如何应用于全球40%居住在热带地区的居民，我们尚无确切了解。本研究采用18F-氟代脱氧葡萄糖正电子发射断层扫描-磁共振成像技术，对居住在巴西东南部热带地区的45名体重正常、超重和肥胖的志愿者进行BAT评估。我们旨在探究BAT活性、体积、代谢活性及其甘油三酯含量与热带地区成年人群的肥胖程度和心血管风险指标之间的关联性。研究结果表明，BAT葡萄糖摄取与体重正常性无相关性；相反，BAT甘油三酯含量与内脏脂肪堆积和心血管风险指标呈相关性。本研究扩展了关于热带地区居民BAT结构和功能的知识，同时，我们提供了证据表明，BAT甘油三酯含量可能成为心血管风险的一个有趣的标志物。