Crystal Structure of SARS-CoV-2 Main Protease (Mpro) in Complex with Inhibitor AVI-4692
收藏Protein Data Bank Japan2025-08-13 更新2026-04-04 收录
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Crystal Structure of SARS-CoV-2 Main Protease (Mpro) in Complex with Inhibitor AVI-4692 Descriptor: (3M,5P,6M)-5-(1H-1,2,3-benzotriazol-1-yl)-6-(3-chlorophenyl)-3-(isoquinolin-4-yl)-1-(prop-2-en-1-yl)pyrimidine-2,4(1H,3H)-dione, (3M,5P,6M)-5-(1H-1,2,3-benzotriazol-1-yl)-6-(3-chlorophenyl)-3-(isoquinolin-4-yl)-1-(prop-2-yn-1-yl)pyrimidine-2,4(1H,3H)-dione, 3C-like proteinase nsp5 Authors: Diallo, A, Gumpena, R, Verba, K. Deposit date: 2025-01-15 Release date: 2025-07-23 Last modified: 2025-08-13 Method: X-RAY DIFFRACTION (1.84 Å) Cite: Structure-based discovery of highly bioavailable, covalent, broad-spectrum coronavirus M Pro inhibitors with potent in vivo efficacy. Sci Adv, 11, 2025
创建时间：
2025-01-15
