Construction of Spiro-Fused 2‑Oxindole/α-Methylene- γ‑Butyrolactone Systems with Extremely High Enantioselectivity via Indium-Catalyzed Amide Allylation of N‑Methyl Isatin
收藏Figshare2016-02-18 更新2026-04-29 收录
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https://figshare.com/articles/dataset/Construction_of_Spiro_Fused_2_Oxindole_Methylene_Butyrolactone_Systems_with_Extremely_High_Enantioselectivity_via_Indium_Catalyzed_Amide_Allylation_of_i_N_i_Methyl_Isatin/2339830
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A remarkably effective method allowing an extremely high enantioselective synthesis of the spiro-fused 2-oxindole/α-methylene-γ-butyrolactones is described. The key strategy lies in the use of indium-catalyzed asymmetric amide allylation of N-methyl isatin with functionalized allylstannanes, which can lead to the antineoplastic spirocyclic lactones in almost enantiopure forms.
创建时间：
2016-02-18
