Construction of Spiro-Fused 2‑Oxindole/α-Methylene- γ‑Butyrolactone Systems with Extremely High Enantioselectivity via Indium-Catalyzed Amide Allylation of N‑Methyl Isatin
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A remarkably effective method allowing an extremely high enantioselective synthesis of the spiro-fused 2-oxindole/α-methylene-γ-butyrolactones is described. The key strategy lies in the use of indium-catalyzed asymmetric amide allylation of N-methyl isatin with functionalized allylstannanes, which can lead to the antineoplastic spirocyclic lactones in almost enantiopure forms.
创建时间：
2016-02-18
