CryoEM structure of PRMT5 bound to covalent PBM-site inhibitor BRD-6988
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CryoEM structure of PRMT5 bound to covalent PBM-site inhibitor BRD-6988 Descriptor: 2-(5-chloro-6-oxopyridazin-1(6H)-yl)-N-(4-methyl-3-{[2-(pyridin-2-yl)ethyl]sulfamoyl}phenyl)acetamide, Methylosome protein 50, Protein arginine N-methyltransferase 5 Authors: McMillan, B.J, McKinney, D.C, Timm, D.E. Deposit date: 2021-03-10 Release date: 2021-03-17 Last modified: 2024-11-06 Method: ELECTRON MICROSCOPY (2.39 Å) Cite: Discovery of a First-in-Class Inhibitor of the PRMT5-Substrate Adaptor Interaction. J.Med.Chem., 64, 2021
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2021-03-10
