Changes in molecular profiles of the left ventricle during progressive dilated cardiomyopathy linked heart failure

To investigate molecular profiles of progressive heart failure, we studied mice that lack expression of the muscle LIM protein (MLPKO). These mice showed dramatic HF progression between three and six weeks of age. We then performed gene expression profile analysis using data obtained from RNA-seq of mid wall left ventricular heart tissue from MLPKO mice and wild-type (WT) controls at three, six, and ten weeks of age (n=3 per group). Comparative gene expression profile analysis of RNA-seq data of heart tissue from three, six, and ten week MLPKO and age matched WT controls.