Phe-Ala-Based Diazaspirocyclic Lactam as Nucleator of Type II′ β-Turn
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https://figshare.com/articles/dataset/Phe_Ala_Based_Diazaspirocyclic_Lactam_as_Nucleator_of_Type_II_Turn/2694280
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资源简介：
The synthesis of a novel Phe-Ala dipeptide mimic, built up on a diazaspirocyclic lactam core, is presented. This new scaffold was evaluated for conformational mimicry of reverse turn by combining molecular modeling, IR, NMR, and X-ray diffraction experiments. All these tools agree on the presence of a strong intramolecular hydrogen bond, thus demonstrating the ability of this spiro compound to act as a type II′ β-turn inducer.
创建时间：
2016-02-23
