Structure of SARM1 bound to M1 and 1AD in the active state

Structure of SARM1 bound to M1 and 1AD in the active state Descriptor: NAD(+) hydrolase SARM1, [(2~{R},3~{S},4~{R},5~{R})-3,4-bis(oxidanyl)-5-(3-sulfanylpyridin-1-yl)oxolan-2-yl]methyl dihydrogen phosphate Authors: Huang, Y, Zhang, J, Zheng, S, Wang, X. Deposit date: 2024-12-17 Release date: 2025-03-19 Last modified: 2025-09-24 Method: ELECTRON MICROSCOPY (3.55 Å) Cite: Stepwise activation of SARM1 for cell death and axon degeneration revealed by a biosynthetic NMN mimic. Proc.Natl.Acad.Sci.USA, 122, 2025