Crystal Structure of Human Beta Secretase in Complex with NVP-BUR436, derived from a soaking experiment
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Crystal Structure of Human Beta Secretase in Complex with NVP-BUR436, derived from a soaking experiment Descriptor: (3R,4S,5S)-3-[(3-tert-butylbenzyl)amino]-5-{[3-(2,2-difluoroethyl)-1H-indol-5-yl]methyl}tetrahydro-2H-thiopyran-4-ol 1,1-dioxide, Beta-secretase 1 Authors: Rondeau, J.M, Bourgier, E. Deposit date: 2012-01-10 Release date: 2012-11-21 Last modified: 2024-11-06 Method: X-RAY DIFFRACTION (1.77 Å) Cite: Discovery of cyclic sulfone hydroxyethylamines as potent and selective beta-site APP-cleaving enzyme 1 (BACE1) inhibitors: structure based design and in vivo reduction of amyloid beta-peptides J.Med.Chem., 55, 2012
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2012-01-10
