Consistency of protection against lethal challenge with malaria parasites in mice immunized with PfCSP-SAPNs.

PfCSP-SAPN vaccines were administrated at wk 0, 2 and 4 in three independent experiments Two wks post 3rd dose of PfCSP-SAPN, C57BL/6 mice were challenged with 5,000 and Balb/C with 10,000, Tg-Pb/PfCSP sporozoites. Shown here are three separate experiments with C57BL/6 mice and two experiments with Balb/C mice. n = 10. Infectivity sham control mice were given PBS. Mice were considered protected if they had no detectable parasitemia by day 15 following challenge. nd = not determined.