Novel drugs used in this study.

Figshare2015-12-02 更新2026-04-29 收录

ABC转运蛋白底物特异性

药物靶点机制

数据链接：

https://figshare.com/articles/dataset/_Novel_drugs_used_in_this_study_/693633 数据链接链接失效反馈

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资源简介：

Drug targets, concentrations, and ABC efflux transporter substrate specificity for novel, targeted drugs.

创建时间：

2015-12-02

DataSheet4_Sodium danshensu attenuates cerebral ischemia–reperfusion injury by targeting AKT1.doc

缺血再灌注损伤

药物靶点机制

The beneficial properties of Sodium Danshensu (SDSS) for controlling cerebral ischemia and reperfusion injury (CIRI) are elucidated here both in vivo and in vitro. SDSS administration significantly im

NIAID Data Ecosystem60

Structural basis of the key residue W320 responsible for Hsp90 conformational change

蛋白质结构解析

药物靶点机制

The 90-kDa heat shock protein (Hsp90) is a homodimeric molecular chaperone with ATPase activity, which has become an intensely studied target for the development of drugs for the treatment of cancer,

Taylor & Francis Group2022-11-14 更新40

Insights into PPARγ Phosphorylation and Its Inhibition Mechanism

药物靶点机制

计算结构生物学

PPARγ represents a key target for the treatment of type 2 diabetes and metabolic syndrome. Synthetic antidiabetic drugs activating PPARγ are accompanied by serious undesirable side effects related to

Figshare2020-04-02 更新20

Targeting KAT6A/KAT6B dependencies in breast cancer with a novel selective, orally bioavailable KAT6 inhibitor, CTx-648/PF-9363 [ChIP-Seq - CUT&RUN]

乳腺癌表观遗传学

药物靶点机制

KAT6A, and its paralog KAT6B, are histone lysine acetyltransferases (HAT) that acetylate histone H3K23 and regulate diverse biological processes including transcription, cell-cycle progression, and st

NIAID Data Ecosystem50

Chemical Systems Biology Reveals Mechanisms of Dissociated Glucocorticoid Receptor Signaling

药物靶点机制

糖皮质激素信号转导

Glucocorticoids display remarkable anti-inflammatory activity, but their use is limited by undesirable on-target effects including insulin resistance and skeletal muscle atrophy. We used a chemical sy

NIAID Data Ecosystem40

Novel drugs used in this study.

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