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Epigenetic regulation of hematopoietic stem and progenitor cells by the Eset histone methyltranferase.

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NIAID Data Ecosystem2026-03-11 收录
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Methylation of histone H3 at lysine 9 (H3K9) mediates heterochromatin formation by forming a binding site for HP1. ERG-associated protein with a SET domain (Eset) or Setdb1E is a methyltransferase which trimethylates H3K9 in the euchromatic region. In mice, homozygous mutations of Eset result in peri-implantation lethality.

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2020-04-09
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