Human Protein Atlas - Blood Atlas

The Blood Atlas contains single cell type information on genome-wide RNA expression profiles of human protein-coding genes covering various B- and T-cells, monocytes, granulocytes and dendritic cells. The single cell transcriptomics analysis covers 18 cell types isolated with cell sorting followed by RNA-seq analysis. In addition, an analysis of the “human secretome” is presented including annotation of the genes predicted to be actively secreted to human blood, as well as the annotation of proteins predicted to be secreted to other parts of the human body, such as the gastric tract and local compartments. An analysis of the proteins detected in human blood is also presented with an estimation of the respective protein concentrations determined either with mass spectrometry-based proteomics or antibody-based immune assays.

《血液图谱》收录了关于人类蛋白质编码基因的全基因组RNA表达谱的单细胞类型信息，涵盖了多种B细胞、T细胞、单核细胞、粒细胞和树突状细胞。该单细胞转录组学分析覆盖了通过细胞分选技术分离的18种细胞类型，并随后进行RNA测序分析。此外，图谱中还展示了‘人类分泌组’的分析，包括预测活跃分泌至人体血液的基因注释，以及预测分泌至人体其他部位（如胃肠道和局部区域）的蛋白质注释。同时，还展示了检测到的人体血液中的蛋白质分析，并估算了相应的蛋白质浓度，这些浓度是通过基于质谱技术的蛋白质组学或基于抗体的免疫分析确定的。