Drug development is both increasing in cost whilst decreasing in productivity. There is a general acceptance that the current paradigm of R&D needs to change. One alternative approach is drug repositi
1)PolyPhen2 scores close to 1 are likely to be pathogenic (highlighted in bold). HumDiv-trained Polyphen-2 assumes even mildly deleterious alleles as damaging to evaluate rare alleles potentially invo
1Adjusted for multiple comparisons (using false discovery rate)2SNP rs3126085 not in Hardy-Weinberg equilibrium3 X chromosome gene, females only4Risk Allele Score: sum of risk allele counts for each o
Unconditioned thoroughbred geldings were exercised to maximal heart rate or fatigue on an equine high-speed treadmill. Skeletal muscle biopsies were taken from the middle gluteal muscle before, immedi
