Amplicon based sequencing of drug resistant lung cancer cell lines
收藏NIAID Data Ecosystem2026-03-10 收录
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资源简介：
A EGFR mutant NSCLC cell line which is sensitive to AZD9291 inhibition was mutagenised with the chemical mutagen ENU and then drug selected using a AZD9291. Single cell derived colonies were then manually picked and expanded in drug. Resistance was confirmed in a 14 day assay and DNA was collected. These then underwent targeted amplicon-based sequencing to confirm candidate resistance effectors hypothesised from currently available literature.EGA study EGAS00001001675
创建时间：
2017-07-26
