Streptomyces ficellus strain:NRRL 8067 Genome sequencing

Streptomyces ficellus NRRL8067 is a Gram-positive bacterium with potential to produce several antibacterial agents such as ficellomycin, which exhibits high activity against Staphylococcus aureus and Penicillium oxalicum. Here we present the complete genome sequence of Streptomyces ficellus NRRL8067, which consists of 7,078,240 bp with a linear chromosome, 6312 protein-coding genes, 18 rRNA operons and 64 tRNAs. The availability of genomic information provides valuable insight for devising rational metabolic engineering strategies for the production and isolation of diverse bioactive antibiotic.

Streptomyces ficellus NRRL8067，一种革兰氏阳性细菌，具备产生多种抗菌剂如 ficellomycin 的潜力，该物质对金黄色葡萄球菌和草酸青霉菌表现出显著活性。本研究中，我们展示了 Streptomyces ficellus NRRL8067 的完整基因组序列，该序列由7,078,240碱基对组成，为线性染色体，包含6,312个编码蛋白质的基因，18个rRNA操纵子以及64个tRNA。基因组信息的提供为制定合理的代谢工程策略，以实现多种生物活性抗生素的生产和分离提供了宝贵的见解。