Gata2 promotes drug resistance in Acute Myeloid Leukemia (AML)

In this study, we generated mouse models of MLL-AF9-driven AML (MA9) harboring conditional alleles for Gata2 gene to precisely investigate the role of Gata2 in drug resistance and progression of MLL-rearranged (MLL-r) AML. Our findings revealed a novel mechanism for Gata2 in blunting p53 mediated apoptosis via transcriptional repression of Rassf4, a regulator of Mdm2 protein stability. ChIP-seq of H3K27ac in murine Gata2 f/f and Gata2 -/- (Gata2 KO) MA9 cells.