Details of the clinical and CSF findings in the enrolled patients with time-matched paired serum and CSF samples

Demographics and clinical features of the enrolled patients with either of
the three demyelinating neurological diseases according to the presence of
disease-specific antibody (MOG-IgG, AQP4-IgG), confirmed by
a live cell-based assay method, are shown in the dataset.
Patients treated in our facility (Tohoku University, Japan) with acute
neurological episodes in whom time-matched paired serum and CSF MOG-IgG
and AQP4-IgG titers were simultaneously evaluated during the acute phase
of the neurological episodes between 2006 and 2020 were initially
recruited. To increase the sample size, eligible data of the
patients from other facilities in Japan were additionally collected. Based
on the results of the MOG-IgG and AQP4-IgG titrations for their serum and
CSF samples, patients were divided into the following four disease groups:
MOG-IgG-associated disease (MOGAD), AQP4-IgG-positive neuromyelitis optica
spectrum disorder (anti-AQP4-positive NMOSD), multiple sclerosis
(MS) without these antibodies, and other conditions. Patients with the
first three disease groups were included for the study.