官方服务：
资源简介：
Microarray analysis of xenograft models in use at the Developmental Therapeutics Program of the National Cancer Institute (DTP-NCI)
应用场景：
创建时间：
2025-01-24
相关数据集
Synthesis, antiproliferative evaluation and in silico studies of new quinazoline derivatives as VEGFR-2 inhibitors
New quinazoline derivatives were designed and synthesized to target VEGFR-2, aiming to identify potential anticancer agents. The synthesized compounds underwent in vitro screening to eva
DataCite Commons2025-07-24 更新770
Design, Synthesis and Evaluation of 4‑Methoxy‑1 H ‑[1,2,3]triazolo[4,5‑ c ]quinolines as Highly Potent and Oral Available RIOK2 Inhibitors
RIOK2 is a promising therapeutic target in cancer due to its pivotal role in tumor progression. Based on our previously identified RIOK2 inhibitor CQ211, we conducted a comprehensive pharmacokinetic o
NIAID Data Ecosystem20
Pharmacokinetic parameters for belinostat after 30 min i.v. infusion in Phase I trial.
Abbreviation: Cmax, maximum concentration; Tmax, time to maximum concentration; AUC0–24 h, area under the curve from 0 to 24 h; T1/2, half-life at the elimination phase; CL, clearance; Vz, volume of d
NIAID Data Ecosystem20
Design, Synthesis, and Biological Investigation of Epothilone B Analogues Featuring Lactone, Lactam, and Carbocyclic Macrocycles, Epoxide, Aziridine, and 1,1-Difluorocyclopropane and Other Fluorine Residues
Despite previous studies within the epothilone field, only one member of this compound family, ixabepilone, made it to approval for clinical use. Recent advances in organic synthesis and medicinal che
NIAID Data Ecosystem40
Design, Synthesis of New Pyrimidine Derivatives as Anticancer and Antimicrobial Agents
A new series of 6-aryl-5-cyano thiouracil derivatives were synthesized. Cyanouracil 1 was condensed with monochloroacetic acid and different aldehydes to give thiazolopyrimidine 2 . On the
Taylor & Francis Group2017-05-26 更新20
