Correlations between CD4 count, peripheral HIV viral load and cervicovaginal lavage HIV viral load with the levels of putative anti-HIV microbicides in the cervicovaginal lavage of HIV-infected women.

CVL levels of the putative endogenous anti-HIV microbicides Elafin and SLPI correlated negatively with the CD4 count, and positively with the CVL HIV viral load. By contrast, the peripheral HIV viral load correlated positively only with CVL levels of SLPI and anti-HIV gp160 IgG.HBD2, human beta defensin 2; Ig, immunoglobulin G; SLPI, secretory leukocyte protease inhibitor.