The HCV Envelope Glycoprotein Down-Modulates NF-κB Signalling and Associates with Stimulation of the Host Endoplasmic Reticulum Stress Pathway

Comparison of cells expressing or not expressing the HCV envelope glycoprotein, E1E2, reveals upregulation of host endoplasmic reticulum stress pathways, including genes such as HSPA5 and ATF3 Transcritome profiles of HEK293T cells transfected with control plasmid compared with those expressing E1E2 using Oxford Nanopore cDNA sequencing method.