Low-dose quercetin positively regulates mouse healthspan
收藏干细胞与再生医学数据中心2022-02-20 更新2024-03-06 收录
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资源简介：
we reported for the first time a geroprotective effect of low-dose quercetin alone that improved the healthspan of aged C57BL/6J male mice. Que-treated mice showed less hair loss, greater athletic endurance, enhanced diastolic function, and less muscle fibrosis, as well as alleviated cellular senescence in multiple tissues. Interestingly, these changes appear to be rarely associated with transcriptional alterations of protein-coding genes but are linked to heterochromatin stabilization and RTE silencing. Que treatment prevented L1 from hyperactivation, thereby inhibiting SASP.
提供机构：
State Key Laboratory of Stem Cell and Reproductive Biology
创建时间：
2022-02-20
