L-Arginine enhances oral keratinocyte proliferation under high glucose conditions through upregulation of CYP1A1, SKP2, and SRSF5

L-Arginine promotes oral keratinocyte proliferation under high glucose conditions. The treatment leads to changes in a substantial number of gene transcripts related to cell cycle, cell proliferation, and spliceosome GO terms as well as signaling pathways. Among these top-upregulated genes, CYP1A1, SKP2, and SRSF5 are of particular significance. Comparative gene expression profiling analysis of RNA-seq data for human gingival keratinocytes (TIGK) cultured under high glucose conditions (48mM) treated with 500uM L-Arginine.