Table_1_Associations of modifiable factors with risk of irritable bowel syndrome.XLSX

BackgroundModifiable factors were found to be associated with the risk of irritable bowel syndrome (IBS) in observational studies, but whether these associations are causal is uncertain. We conducted a Mendelian randomization (MR) study to systematically explore the causal associations of modifiable factors with IBS.MethodsSummary-level statistical data for IBS was obtained from a genome-wide association study (GWAS) meta-analysis of UK Biobank (40,548 cases and 293,220 controls) and the international collaborative Bellygenes initiative (12,852 cases and 139,981 controls). Genetic instruments associated with the exposures at the genome-wide significance (p

背景因素在观察性研究中被发现与肠易激综合症（IBS）的风险相关，但这些关联是否具有因果关系尚不明确。本研究通过孟德尔随机化（MR）方法，系统性地探讨了可修改因素与IBS之间的因果关联。研究方法：通过UK Biobank（40,548例病例和293,220例对照）的全基因组关联研究（GWAS）荟萃分析和国际协作的Bellygenes倡议（12,852例病例和139,981例对照）的GWAS荟萃分析，获得了IBS的汇总统计数据分析。与全基因组显著性（p-value）相关的遗传工具与暴露相关。