Phenotypic effects of solvents and carriers above maximum tolerated concentrations after 24 hours.*

*Phenotypes with an average penetrance of at least 50% (in comparison to dead or apparently normal embryos or larvae) are indicated by the following abbreviations: AH, atrial hemorrhage; AP, anterior-posterior axis truncation; BC, body curvature; BH, brain hemorrhage; BS, brain segmentation defects; CB, cardia bifida; CF, widened choroid fissure; CY, cyclopia; DD, developmental delay; DH, delayed hatching; EH, elongated heart; EP, epiboly defects; GG, bright green gall bladders; HJ, hypomorphic jaw; HO, hypoactivity; HY, hyperactivity; IC, impaired circulation; IM, impaired motility (lack of touch response); IP, incomplete pigmentation; LP, loss of posture; MC, microcephaly; NB, necrosis in body cavity; NH, necrosis in head; NO, bumpy notochord; PE, pericardial edema; SB, incompletely inflated or uninflated swim bladder; SB+, enlarged swim bladder; SO, somite defects; YE, yolk sac edema. Phenotypes were not recorded for penetrance levels below 50% (i.e. where the majority of embryos or larvae were dead or apparently normal); these cases are denoted by “-”. The lowest concentration (in % of solvent or carrier) at which an average penetrance of at least 50% was observed for the shown phenotypic effects is given in parentheses.