Crystal structure of Akt1 in complex with a selective inhibitor
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Crystal structure of Akt1 in complex with a selective inhibitor Descriptor: (5R)-4-(4-{4-[4-fluoro-3-(trifluoromethyl)phenyl]-1-[2-(pyrrolidin-1-yl)ethyl]-1H-imidazol-2-yl}piperidin-1-yl)-5-methyl-5,8-dihydropyrido[2,3-d]pyrimidin-7(6H)-one, RAC-alpha serine/threonine-protein kinase,PIFtide Authors: Wang, Y, Stout, S. Deposit date: 2018-02-07 Release date: 2018-05-02 Last modified: 2024-11-20 Method: X-RAY DIFFRACTION (2.18 Å) Cite: Discovery of chiral dihydropyridopyrimidinones as potent, selective and orally bioavailable inhibitors of AKT. Bioorg. Med. Chem. Lett., 28, 2018
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2018-02-07
