Physiological data and PBK model code for chicken

This excel file provides physiological parameters and their inter-individual variability (mean, coefficient of variation, sample size) for chicken (<em>Gallus gallus domesticus</em>). These physiological parameters were estimated based on the results of extensive literature searches and specific experimental data described in Lautz et al., (2020). The R code presented here constitute generic physiologically based model for chicken. In addition, the function “soboljansen” was used to carry out sensitivity analysis using sobol plots. Each generic PBK model includes: 1. A deterministic modelling method, which represents only a single animal. 2. A probabilistic modelling approach to simulate the individual differences of the physiology within a population. Sensitivity analyses can be performed to identify which parameters have the most impact on the model’s outputs. Predictions can be compared with experimental data. Our model can be used to assess the influence of physiological factors on the kinetic of chemicals and provide guidance for assessing such critical factors in animal risk assessment. For PBK modelling purposes, species and chemical specific kinetics (e.g clearance, absorption rate, etc…) should be provided by the user. The full data collection and implementation of the models using case studies are described in Lautz et al., 2020 (DOI: 10.1016/j.envint.2020.105488).