Reverse myocardial remodeling by aortic bending debanding in mice. Mus musculus

The objective of this study was to identify alterations in gene expression during reverse myocardial remodeling in a mouse model of reversible pressure overload. Mice were subjected to 4 weeks of aortic banding (AB) or sham procedure (sAB), banding and subsequent debanding (DB3), or sham procedure and subsequent debanding (sDB3), with saccrifice 3 days after debanding. Overall design: Microarray screening was performed in 3 mice from each group. Sham was used as control, and we used an ANOVA model for each gene programmed in R-script to identify the effect of debanding.