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Supplementary Table 4 from Histone H3.3 Mutations Drive Pediatric Glioblastoma through Upregulation of MYCN

Figshare2013-05-01 更新2026-04-28 收录

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https://figshare.com/articles/dataset/Supplementary_Table_4_from_Histone_H3_3_Mutations_Drive_Pediatric_Glioblastoma_through_Upregulation_of_MYCN/22529429 数据链接链接失效反馈

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PDF file - 32K, Paediatric GBM tissue microarray samples.

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创建时间：

2013-05-01

儿童胶质瘤

表观遗传学

Recent studies have identified a Lys 27-to-methionine (K27M) mutation at one allele of H3F3A, one of the two genes encoding histone H3 variant H3.3, in 60% of high-grade pediatric glioma cases. The me

NIAID Data Ecosystem100

A mutation in histone H2B Represents a new class of oncogenic driver

癌症表观遗传学

组蛋白突变机制

The goal of this study was to determine the mechanism by which a glutamate to lysine mutation of histone H2B at amino acid 76 (H2B-E76K), found particularly in bladder and head and neck cancer, may pr

NIAID Data Ecosystem40

Generating in vivo somatic mouse mosaics with locus-specific, stably-integrated transgenic elements for studies of gene function in development and tumorigenesis [scRNA-seq]

儿童胶质瘤

单细胞测序

We report the development and eficiency of a new method to create somatic mosaicism in mice named as mosaic analysis by dual recombinase-mediated cassette exchange. Then we generate, as a proof of con

NIAID Data Ecosystem40

PRC2-indepdendent actions of H3.3K27M in embryonic stem cell differentiation

胚胎干细胞分化

组蛋白突变机制

The histone H3 variant, H3.3, is localized at specific regions in the genome, especially promoters and active enhancers, and has been shown to play important roles in development. A lysine to methioni

NIAID Data Ecosystem70

Single substitution in H3.3G34 alters DNMT3A recruitment to cause progressive neurodegeneration [multiome]

神经退行性疾病表观遗传

组蛋白突变机制

Germline histone H3.3 amino acid substitutions, including H3.3G34R/V, cause severe neurodevelopmental syndromes. To understand how these mutations impact brain development, we generated H3.3G34R/V/W k

NIAID Data Ecosystem40

Supplementary Table 4 from Histone H3.3 Mutations Drive Pediatric Glioblastoma through Upregulation of MYCN

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