reversible and irreversible Thy-1 nephritis. Rattus norvegicus

To identify genes that play an important role in the irreversible progression of renal injury, we used microarray technology to identify differences in gene expression between these models. Keywords: time course Overall design: Rats were intravenously injected with mAb 1-22-3 one week after unilateral nephrectomy (irreversible model) or a sham operation (reversible model), and rats were sacrificed on day 4, 7, 14, 42, and 56 after the injection. cDNA probes prepared from kidney mRNAs were hybridized with oligonucleotide microarrays containing 4854 rat genes.