Inflammation induced by incomplete radiofrequency ablation accelerates tumor progression and hinders PD-1 immunotherapy
收藏NIAID Data Ecosystem2026-04-25 收录
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High-throughput RNA-seq analysis was performed using fresh residual CT26 tumors 3 days after incomplete radiofrequency abaltion (iRFA) as well as control tumors. We ound genes encoding damage-associated molecular patterns molecules (DAMPs), proinflammatory cytokines, chemokines, and genes associated with immunosuppression were overexpressed in the iRFA-treated tumor, indicating iRFA elicits inflammation and induces immunosuppression in residual tumors. Overall design: Tumor mRNA profiles of CT26 colon cancer in Balc/c mice in two different groups (control and iRFA ) were generated by deep sequencing, in triplicate.
创建时间：
2020-01-02
