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Total Synthesis of (+)-Lepadin F

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NIAID Data Ecosystem2026-03-06 收录
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An enantioselective total synthesis of (+)-lepadin F is described. The synthetic sequence features an intermolecular aza-[3 + 3] annulation, homologation of a vinylogous amide via Eschenmoser’s episulfide contraction, and a highly stereoselective hydrogenation essential for achieving the 1,3-anti relative stereochemistry at C2 and C8a.

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2008-11-06
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