Identification of cardiac myosin heavy chain post-translational modifications in hibernating grizzly bears

Mammal hibernation is a physiological process with unclear molecular mechanisms. Here, we aimed to investigate whether cardiac myosin heavy chain post-translational modifications would be affected by hibernation. For that, we used cardiac left ventricle specimens from active and hibernating adult grizzly bears. We then defined the nature and location of cardiac myosin heavy chain post-translational modifications using LC/MS.