T2 cells expressing a library of off targets (derived from A6 and B7 binding motifs in Hausmann 1999) are co-cultured with A6, B7. DMF5 or 1G4 expressing T cells (from a non-A2 donor) and minigenes fr
Validate the antigenic specificity of TCRs produced by Stitchr from published V/J/CDR3 information, by cloning the sequences produced into CD8+ TCR-deficient Jurkat cells. Target cells either positive
To determine the underlying mechanism within tumor-specific TMV cells that eliminates solid tumors with antigen heterogeneity, we used RNA-seq to analyze the global RNA expression of tumors Overall de
The study explore the intrinisic inhibitors of antigen experienced Marilyn CD4 T cells (TCR-Tg) expansion after footpad vaccinations in vivo and in the presence of a first cohort of expanded Marilyn c
One major immunological question concerns antigenic differences between SARS-CoV-2 and SARS-CoV-1. We address this question by analyzing plasma from patients infected by SARS-CoV-2 or SARS-CoV and fro