RNA-seq data of mouse liver treated with TCPOBOP

The constitutive androstane receptor (CAR) regulates genes that detoxify drugs and xenobiotics. We report the transcriptomic response of mouse liver when treated with TCPOBOP, a potent CAR ligand, over a period of 24 hours. Gene expression profiles identified expected stimulation of genes with detoxification function. We also see that CAR both stimulated and inhibited target genes in lipid, carbohydrate and energy metabolism. Our results indicate that interaction between CAR and other nuclear receptors plays an important role in integration of these liver metabolism pathways.