five

Cost-free lifespan extension via optimisation of gene expression in adulthood aligns with the developmental theory of ageing

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Figshare2020-07-17 更新2026-04-28 收录
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https://figshare.com/articles/dataset/Cost-free_lifespan_extension_via_optimisation_of_gene_expression_in_adulthood_aligns_with_the_developmental_theory_of_ageing/12666416
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Data for the following manuscript: https://www.biorxiv.org/content/10.1101/739490v1Please see manuscript for methods and analyses.Provided are files for Lifespan, Reproduction and Egg size for C. elegans worms subjected to Control (empty vector) or RNAi against one of five five different genes: age-1, ife-2, ifg-1, nuo-6 or raga-1. RNAi have either been lifelong (L), during adulthood (D1=from day1 of adulthood) or post-reproductive (D6=from day 6 of adulthood).In addition, we also provide QPCR data on gene expression downregulation of the five genes when using RNAi, see methods for details.Some data provided may not be included in the analysis, please see supplementary methods for details.For the lifespan files, Event is coded as follows:Event: 1=Dead (natural death or matricide), 0=CensoredMatricide: 1=MatricideEventWOM: 1=Dead (natural death), 0=Censored (including matricide as censored)EventWOM is the one used in analyses.
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2020-07-17
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