Protein C-Terminal Variations Broadly Impact Proteostasis

NIAID Data Ecosystem2026-05-10 收录

蛋白质C末端变异

蛋白质稳态

数据链接：

https://figshare.com/articles/dataset/Protein_C-Terminal_Variations_Broadly_Impact_Proteostasis/30101461 数据链接链接失效反馈

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资源简介：

Data source for the manuscript "Protein C-Terminal Variations Broadly Impact Proteostasis"

创建时间：

2026-03-11

Cellular proteostasis collapse in mammalian senescence

衰老生物学

蛋白质稳态

Proteostasis collapse, the diminished ability to maintain protein homeostasis, has been established as a hallmark of nematode aging. However, whether proteostasis collapse occurs in humans has remaine

干细胞与再生医学数据中心2022-02-20 更新80

The Plasmodium falciparum exported J domain proteins fine-tune human and malarial Hsp70s: Pathological exploitation of proteostasis machinery

疟原虫机制研究

蛋白质稳态

This dataset represents the documentation and supporting information for the following published review article submitted to Frontiers in Molecular Biosciences: "The Plasmodium falciparum exported J d

NIAID Data Ecosystem40

Gene Expression Profiling in Tibial Muscular Dystrophy Reveals Unfolded Protein Response and Altered Autophagy

疾病分子病理学

蛋白质稳态

Tibial muscular dystrophy (TMD) is a late onset, autosomal dominant distal myopathy that results from mutations in the two last domains of titin. The cascade of molecular events leading from the causa

Figshare2016-01-18 更新20

SQSTM1/p62-mediated autophagy compensates for loss of proteasome polyubiquitin recruiting capacity

蛋白质稳态

选择性自噬机制

Protein homeostasis in eukaryotic cells is regulated by 2 highly conserved degradative pathways, the ubiquitin-proteasome system (UPS) and macroautophagy/autophagy. Recent studies revealed a coordinat

NIAID Data Ecosystem70

Proteasome dysfunction induces excessive proteome instability and loss of mitostasis that can be mitigated by enhancing mitochondrial fusion or autophagy

蛋白质稳态

线粒体稳态调控

The ubiquitin-proteasome pathway (UPP) is central to proteostasis network (PN) functionality and proteome quality control. Yet, the functional implication of the UPP in tissue homeodynamics at the who

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Protein C-Terminal Variations Broadly Impact Proteostasis

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