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Selective Activation of Enantiotopic C(sp3)−Hydrogen by Means of Chiral Phosphoric Acid: Asymmetric Synthesis of Tetrahydroquinoline Derivatives

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Figshare2016-02-23 更新2026-04-29 收录
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https://figshare.com/articles/dataset/Selective_Activation_of_Enantiotopic_C_sp_sup_3_sup_Hydrogen_by_Means_of_Chiral_Phosphoric_Acid_Asymmetric_Synthesis_of_Tetrahydroquinoline_Derivatives/2659165
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Chiral phosphoric acid-catalyzed asymmetric C−H functionalization has been achieved. In this process, enantiotopic C(sp3)−hydrogen is selectively activated by chiral phosphoric acid to afford tetrahydroquinoline derivatives with excellent enantioselectivities (up to 97% ee).
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2016-02-23
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