Multiparametric Magnetic Resonance Imaging (MRI) as an Outcome Predictor for Anal Canal Cancer Managed with Chemoradiotherapy

Interventions: Single arm, multicentre, prospective, observational biomarker study.
Patients will have standard chemotherapy and radiotherapy. Patients participating in this study will have a multiparametric MRI at the following four time points:
1. Prior to chemoradiotherapy
2. During the second week of treatment
3. During the fourth week of treatment
4. At 6-8 weeks post treatment
A Multiparametric MRI incorporates standard morphological as well as diffusion weighted and dynamic contrast enhanced sequences. Each MRI takes approximately 45 minutes. All sequences will be performed on all patients at each of the 4 time points.
Observation post treatment is for 6 months.
Primary outcome(s): Correlation of change in Standard Morphological MRI with tumour response as determined by DRE +/- imaging [6 months];Correlation of change in Diffusion Weighted MRI with tumour response as determined by DRE +/- imaging[6 months];Correlation of change in Dynamic Contrast Enhanced MRI with tumour response as determined by DRE +/- imaging
[6 months]