Expression of the olfactory receptors OR6X1 and OR4E2 decreases in hypothyroidism and is reversible with levothyroxine treatment in pregnancy

These libraries reflect a part of a large study. We construct transcriptome libraries, using whole blood circulating RNAs, of four healthy pregnancy (CTL) and preeclamptic women (PEC). In the manuscript, we perform an edgeR three-group analysis comparing the libraries of healthy thyroid pregnancy (HTP), gestational hypothyroidism (GHT) and preeclampsia (PEC). The HTP and GHT libraries are available in GSE147527. As a result, we obtained 1276 DEG in GHT and 1185 DEG in PEC. We also found 195 olfactory receptors common between only in GHT and PEC. Overall design: We constructed libraries of four healthy pregnancy (CTL) and four preeclamptic women (PEC). The whole blood was collected in the PAXgene Blood RNA tube (QIAGEN, NL, DE) and the RNA was extracted by PAXgene Blood RNA tube (QIAGEN, NL, DE). The sequencing was carried out using an Ion PI Chip (Thermo Fisher Scientific) in an Ion Proton Sequencer (Thermo Fisher Scientific).