The polyglutamine expansion of huntingtin (mHtt) causes Huntington disease (HD) and neurodegeneration, but the mechanisms remain unclear. Here, we found that mHtt promotes ribosome stalling and suppre

NIAID Data Ecosystem80

Crystal Structure of Frameshift Suppressor tRNA SufA6 Bound to Codon CCG-G on the Ribosome

核糖体调控

tRNA-密码子相互作用

Crystal Structure of Frameshift Suppressor tRNA SufA6 Bound to Codon CCG-G on the Ribosome

NIAID Data Ecosystem40

mSeq of total and polysome bound mRNAs in two yeast strains

核糖体调控

翻译组学

We report on how the association of mRNA to translating ribosomes changes due to the absence of the expansion segment 27L in S. cerevisiae. We observe specific enrichment and depletion of mRNA sets fr

NIAID Data Ecosystem90

Deregulation of ribosomal protein expression and translation promotes breast cancer metastasis [ribo-Seq BRx142]

癌症转移机制

核糖体调控

We conducted an in vivo genome-wide CRISPR activation screen to identify genes that accelerate distal metastasis by breast cancer patient-derived circulating tumor cells (CTCs) following direct intrav

NIAID Data Ecosystem70

Ribosomal frameshifting is a carefully tuned modifier of proteins

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