FOXP2 expression was decreased in placental tissue sample of patients with preeclampsia compared with healthy pregnant women

Preeclampsia (PE) is a common pregnancy disorder, and it complicates 5~7% of all pregnancies. At present, termination of pregnancy is the only curative strategy for PE. To explore a potential target for PE treatment, we collected placental tissue samples from patients with preeclampsia (PE) and normal pregnant women (N), and performed high-throughput RNA sequencing. We found that FOXP2 was significantly downregulated in placental samples of patients with PE compared with the controls. Overall design: In the present study, placental tissue samples were collected from patients with PE (n = 6) and normal pregnant women (n = 6) and used for high-throughput RNA-sequencing to analyze gene expression profiles.