Visible Light Mediated Organocatalytic Activation of Ethyl Bromofluoroacetate: Coupling with Indoles and Anilines

The
activation of ethyl bromofluoroacetate employing a visible
light mediated, Eosin Y catalyzed photoredox transformation is reported.
Using indoles and anilines as nucleophiles, the reaction leads to
the formation of two Csp2–Csp3 bonds resulting in an efficient synthesis of bisindolyl
and bisanilinoyl acetate derivatives. Application of this method to
the direct synthesis of unsymmetrical diarylacetates featuring indoles
and N-substituted anilines was also demonstrated.