NGS data from: Predominant HDR-dependent genome editing and prevention of byproducts by DNA repair pathway choice
收藏DataCite Commons2025-05-01 更新2025-04-09 收录
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https://datadryad.org/dataset/doi:10.5061/dryad.fj6q5740f
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资源简介：
CRISPR-Cas9 genome editing has been widely adapted to cleave genomic DNA
sequences of interest. Cellular repair of the CRISPR induced DNA
double-strand breaks is dominated by error prone end joining pathways that
outcompete inefficient homology-directed repair (HDR) that would allow
precise introduction of a mutation present in a supplied synthetic DNA
donor. To achieve predominant HDR, we studied the combinatory effect of
inhibitory mutations in genes that are central to competing repair
pathways.
提供机构：
Dryad
创建时间：
2023-04-28
