Crystal structure of the catalytic domain of human PDE3A bound to Trequinsin

Crystal structure of the catalytic domain of human PDE3A bound to Trequinsin Descriptor: (2E)-9,10-dimethoxy-3-methyl-2-[(2,4,6-trimethylphenyl)imino]-2,3,6,7-tetrahydro-4H-pyrimido[6,1-a]isoquinolin-4-one, ACETATE ION, MAGNESIUM ION, ... Authors: Horner, S.W, Garvie, C. Deposit date: 2020-12-16 Release date: 2021-06-16 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (2.2 Å) Cite: Structure of PDE3A-SLFN12 complex reveals requirements for activation of SLFN12 RNase. Nat Commun, 12, 2021