RNA sequencing data of paired parental and therapy resistant cancer cell lines transfected with negative control siRNA's or a pool of siRNA's targeting DNMT1, DNMT3A and DNMT3B

RNA sequencing data of paired parental and therapy resistant cancer cell lines. Parental cell lines are mostly established cell lines. Resistant cell lines were obtained through long term exposure of the parental cells to gradually increasing doses of cancer therapies. Samples include 7 parental and 10 derived resistant cell lines. Our aim was to assess whether the resistant cells had undergone Epithelial to Mesenchymal Transition upon resistance acquisition and whether EMT disappears upon knock down of the DNMTs RNA from in total 12 samples (3 parental cell lines, 3 derived resistant cell lines, each transfected with control siRNA's or siRNAs targeting the DNMTs) processed according to standard Illumina protocols.